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KMID : 0370219970410040533
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Yakhak Hoeji
1997 Volume.41 No. 4 p.533 ~ p.537
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Characteristics of the Resistance Phenotypes by Inducible Resistance Gene ermK and Its Terminator Region Mutants
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최성숙/Choi SS
최응칠/Choi EC
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Abstract
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The characteristics of the resistance phenotypes of Bacillus subtilis having ermk and its terminator region mutants were determined. Wild type ermK(pEC101) and pECMT109(methylase SD-region mutant) showed typical inducible resistance phenotype. pECMF1(terminator1 region mutant) and pECMT2(terminator2 region mutant) showed constitutive resistance to Kitasamycin but inducible resistance to tylosin. In contrast, pECMT3(terminator1 and terminator2 double mutant) and pECMT309(terminator1, terminator2 and methylase SD region triple mutant) showed constitutive resistance both to kitasamycin and tylosin.
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KEYWORD
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